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THE SCIENCE OF REGENERATIVE BIOLOGICS

The content on this page is for educational and informational purposes only and should not be considered medical advice or used to treat any disease or condition.
Science of EVsClinical Research & DevelopmentPublications

The Science of evs

ZEO ScientifiXTM  biologics are supported by pre-clinical and clinical research studies. Research has demonstrated that these extracellular vesicles are able to reduce inflammation and promote tissue regeneration. *Bellio MA, cytotherpy publication

EVs are known as significant mediators of cell-to-cell communication and have a positive effect on reducing inflammation and promoting tissue healing and regeneration* DelRivero et al. Frontiers in Immunology. They convey active biomolecules to target cells and have vital functions in several physiological and pathological processes. EV biologics increasingly show substantial promise as novel treatment strategies for a variety of diseases and applications.

Science of extracellular vesicles

What are exosomes?

Exosomes are a type of extracellular vesicle produced in the endosomal compartment of eukaryotic cells, with specialized functions in various physiological processes. They are composed of a lipid bilayer membrane and typically range from 50 to 100 nm in size.

Due to their endosomal origin, exosomes carry a high concentration of small nucleic acids and protein cargo. EVs are released by many different cell types. Depending on their origin, they can alter the fate of recipient cells according to the information transferred.

Their “cargo” is very cell-specific, loaded with microRNAs (miRNA) and other bioactive contents including RNA, lipids, enzymes, and cell-surface proteins.

The messengers

Extracellular vesicles (EVs) consist of bioactive proteins, and other nanoparticles, which are released directly from the cell membrane. EVs can mediate cell–cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation.

EV’s are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EVs may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation. 1

Growth factors & cytokines

Growth factors are proteins that may act locally or systemically to affect the growth of cells in several ways. Various cell activities, including division, are influenced by growth factors.

Cytokines are small proteins that are crucial in controlling the growth and activity of other immune system cells and blood cells. When released, they signal the immune system to do its job. Cytokines affect the growth of all blood cells and are responsible for regulating the immune response, inflammation, tissue remodeling and cellular differentiation.

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling.3
REFERENCES:
1 Extracellular Vesicles: Potential Roles in Regenerative Medicine Olivier G. De Jong, Bas W. M. Van Balkom, Raymond M. Schiffelers, Carlijn V. C. Bouten, Marianne C. Verhaar. Front Immunol. 2014; 5: 608.
2 Effie Ioannidou, “ Therapeutic Modulation of Growth Factors and Cytokines in Regenerative Medicine”, Current Pharmaceutical Design (2006) 12: 2397.
3 U.S. National Library of Medicine, G04.085.600, Paracrine Communication, Cellular signaling in which a factor secreted by a cell affects other cells in the local environment.

clinical research and development

One of the nation’s leading therapeutics research company pioneering innovative nano-technologies to address a broad range of critical medical conditions.

ind clinical trial pipeline

IRB Approved Clinical trials

Peer-reviewed publication library

Viruses
Jan 2024
Acellular human amniotic fluid-derived extracellular vesicles as a novel anti-inflammatory therapeutic against SARS-COV-2 Infection
Molecular Therapy
May 2023
Extracellular Vesicles: A promising therapy against SARS-CoV-2 infection
Frontiers in Immunology
Nov 2022
Human amniotic fluid derived extracellular vesicles attenuate T Cell immune response
Cytotherapy
Dec 2021
Amniotic fluid-derived extracellular vesicles: characterization and therapeutic efficacy in an experimental model of bronchopulmonary dysplasia.
Biomaterials and Biosystems
Dec 2021
Proof-of-concept trial of an amniotic fluid-derived extracellular vesicle biologic for treating high risk patients with mild-to-moderate acute COVID-19 infection, Biomaterials and Biosystems
Respiratory Medicine Case Reports
Nov 2021
Treatment of a COVID-19 long hauler with an amniotic fluid-derived extracellular vesicle biologics
Frontiers in Medicine
Mar 2021
Case Report: Administration of Amniotic Fluid-Derived Nanoparticles in Three Severely Ill COVID-19 Patients

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*Senate Bill 1768 became law in Florida on July 1, 2025 and amended FS §458.3245 and FS§459.0127, making stem cell therapies, as defined in the statute, available for the following therapeutic indications: orthopedics, wound care, and pain management.
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*The material on this site is intended for general informational and educational purposes only and is not intended to provide medical advice, diagnosis, or treatment recommendations. ZEO ScientifiX doesn’t make any medical claims regarding any of these products. ZEO ScientifiX does not offer medical services to the public and does not endorse or guarantee any third-party products or services referenced. Content may reference investigational biologics or devices not approved by the FDA. If you are a patient please consult your physician for further information. Any mention of product usage are for therapeutic use only in the states of Florida and Utah. Certain information provided herein is intended only for those that may fall under the new Florida stem cell law in effect as of July 1, 2025. Subject to change without notice.